The council hopes to create an Olympic host destination and is about to begin the procurement process, Property Week has reported.
It hopes to set up an asset-backed vehicle to develop 11 sites, with an eventual post development value of more than £800 million.
Newham is aiming to develop a mixture of commercial property and residential housing, although definite plans are yet to be finalised.
The council has recently selected two new consortia, Bouygues and E-Central, to work on the regeneration of Canning Town and Custom House.
Mayor of Newham, Sir Robin Wales, said he hoped the partnership "will result in delivering much-needed economic investment and prosperity for the area".
