A redevelopment of the Thames Gateway is likely to see around 11.8 million square feet of office space built in the London area.
Prime minister Gordon Brown has pledged to put forward £9 billion towards the project, with much of this total earmarked for improving local schools and infrastructure.
"It is about the wholesale regeneration of the area but it is also about more than regeneration," Gordon Brown said as he unveiled details of the new project.
"It is a historic endeavour to bring so many people of determination and initiative together to create one of the most vibrant and successful areas in the world.
"It is about the wholesale regeneration of the area but it is also about more than regeneration.
"A place for people to work, to live, and to bring up a family," the prime minister added.