Transport for London (TfL) has agreed to move to new offices in London.
The group will take two floors in the first building of Meridian Delta’s Greenwich Peninsula development.
Designed by Terry Farrell & Partners the build is not due for completion until this summer.
Meridian Delta is a joint venture between Lend Lease and Quintain (L&Q). Once work has completed, Greenwich Peninsula will offer homes for 25,000 people and jobs for 24,000 people.
The development is set to benefit from £100 million invested to build schools, health facilities and create 48 acres of natural space.
“Greenwich Peninsula is one of many projects that L&Q will help deliver over the next ten years,” said chief executive Don Wood.
As a mix of commercial property and homes, the redevelopment will help the government toward its housing target.
Visiting the site, the housing minister Yvette Copper said: “We must make sure that the homes of the future are sustainable as well as affordable and the types of housing are places where people want to live.”